* Ensures greater bioavailablity * Ensures uniform emptying of micro pellets from stomach into small intestine facillitates rapid dissolution enteric coating and drug release resulting in early Tmax and Cmax (peak time and peak plasma concentration) * Ensure lesser possiblility of dose dumping * Is a combination of fast acting and sustained action * Ensures uniform drug release * One daily dosing * Ensures lesser chance of localized irritation * Ensures better and more uniform drug absorption * Is better than capsules in reducing the esophageal residence time * Minimizes fluction in plasma concentration of drug.
Pharmacodynamic Advantages
* MUPS ensure rapid and uniform gastric emptying and subsequently uniform drug dissolution of pellets in the gastrointestional tract due to their small size and large surface, uniform drug absorption is facilitated which results in consistent and controlled pharmacological action.
* A further reduction in inter and intra-subject variability in drug absorption and clinical response is facilitated since the member of pellets per MUPS dosage from is much more than a conventional pellet-filled capsule and possibility of dose dumping (in stomach) and incomplete drug release is further minimized.
Indication
* Gastroesophageal reflux disease (GERD): Treatment of erosive reflux-Maintenance of heald oesophagitis to prevent recurrences. – Symptomatic treatment of gastroesophageal reflux. * Eradication of Helicobacter pylori in combination with appropriate antibiotics: At the healing of Helicobacter pylori associated duodenal ulcer. – For the prevention of relapse of Helicobacter pylori associated peptic ulcers. * Patients who have required a continuous NSAID treatment: At the healing of NSAID-associated gastric ulcers. For the prevention of NSAID-associated gastric and duodenal ulcers in patinets at risk. Duodenal and Gastric Ulcer- Zollinger-Ellison Syndrome.
Dosage & Administration